| 来源类型 | Article
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| 规范类型 | 其他
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| DOI | 10.1016/j.tree.2018.02.004
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| Beyond R 0 Maximisation: On Pathogen Evolution and Environmental Dimensions. |
| Lion S; Metz H
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| 发表日期 | 2018
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| 出处 | Trends in Ecology & Evolution 33 (6): 458-473
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| 出版年 | 2018
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| 语种 | 英语
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| 摘要 | A widespread tenet is that evolution of pathogens maximises their basic reproduction ratio, R0. The breakdown of this principle is typically discussed as exception. Here, we argue that a radically different stance is needed, based on evolutionarily stable strategy (ESS) arguments that take account of the ‘dimension of the environmental feedback loop’. The R0 maximisation paradigm requires this feedback loop to be one-dimensional, which notably excludes pathogen diversification. By contrast, almost all realistic ecological ingredients of host–pathogen interactions (density-dependent mortality, multiple infections, limited cross-immunity, multiple transmission routes, host heterogeneity, and spatial structure) will lead to multidimensional feedbacks. |
| 主题 | Evolution and Ecology (EEP)
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| 关键词 | pathogen evolution
virulence
basic reproduction ratio
evolutionary optimisation
enviromental feedback
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| URL | http://pure.iiasa.ac.at/id/eprint/15223/
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| 来源智库 | International Institute for Applied Systems Analysis (Austria)
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| 引用统计 |
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| 资源类型 | 智库出版物
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| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/131327
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推荐引用方式
GB/T 7714 |
Lion S,Metz H. Beyond R 0 Maximisation: On Pathogen Evolution and Environmental Dimensions.. 2018.
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文件名：
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LionMetz-R0.pdf
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格式：
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Adobe PDF
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