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Studies evaluated diverse provider interventions to promote uptake of clinical practice guidelines and guideline-concordant practices

• Twenty-two randomized controlled trials promoting uptake of clinical practice guidelines or guideline-concordant practices met inclusion criteria.
• Results were heterogeneous and analyses comparing interventions with usual clinical practice did not indicate a statistically significant difference in guideline adherence across studies.
• There was some indication that more complex interventions may be associated with larger intervention effects and that interventions can improve individual outcomes such as medication prescribing.
• Due to the small number of studies reporting team interventions or interventions in specialty care, robust evidence that effects vary by provider group or setting could not be reported.
• Effects on patients' health were mixed across studies and outcomes, but interventions improved the number of patients responding to treatment.
• The low quality of evidence and lack of replication of specific intervention strategies across studies limit the conclusions that can be drawn from the current literature.